Come along and find out more about FerAppease mBAS on February 5th - Stand P110! Win one of nine 10-dose packs, plus giveaways including hats, mugs, and keyrings.
Come along and find out more about FerAppease mBAS on February 5th - Stand P110! Win one of nine 10-dose packs, plus giveaways including hats, mugs, and keyrings.
SCIENTIFICALLY PROVEN • REVOLUTIONARY
FerAppease mBAS is the newly-available, non-medicinal product for the UK market to reduce the impact of stress in cattle of all ages.
Shift Cattle from Surviving to Thriving
Maternal Bovine Appeasing Substance (mBAS) is a naturally occurring pheromone that is secreted by the skin of the mammary gland of lactating animals and functions to reduce the impact of stress and the production of cortisol, also known as the stress hormone.
The active ingredient of FerAppease is a synthetic analogue of the mBAS, specifically created to mitigate stress in healthy calves and adult cattle.
FerAppease is widely used in US dairy and beef production systems with over 15 million doses sold in the last 12 months.
FerAppease is available from veterinarians — no prescription needed.
Applied as a spot-on, FerAppease can be used on healthy cattle when any routine on-farm task can raise stress levels.
- Weaning
- Calving
- Drying off
- Dehorning
- Castration
- Vaccination
- TB testing
- Transportation
- Moving and mixing
FerAppease is applied topically to the skin above the muzzle and in the divot behind the poll where it is then inhaled by the vomeronasal organ, leading to the desensitization of areas of the brain that are responsible for sending signals to the adrenal glands where cortisol is produced, blocking cortisol, thus mitigating stress. The response has been shown within 30 minutes of application and lasts at least 14 days.
FerAppease is available from veterinary surgeons.
It is a non-medicinal product. Prescription is not needed.
FerAppease is Available from Veterinary Surgeons
It is a non-medicinal product. Prescription is not needed.
Reported Data
WEANED BEEF CALVES
"Across all the studies that we ran, we typically saw a 15-20% increase in average daily gain post-weaning in calves that received the analogue at the time of weaning."
— Dr. Reinaldo Fernandes Cooke, PhD, Department of Animal Science, Texas A&M University
BEEF CALVES
FerAppease decreased Cortisol levels 4 hours post-castration by 45.6%
BEEF CALVES
FerAppease decreased Substance-P levels 4 hours post-castration by 15.3%
HOLSTEIN CALVES
FerAppease decreased the incidence of scours by 8.8% and reduced treatment costs for scours by 63%
FRESH HEIFERS
FerAppease increased daily milk production by 5% over the first 60-days of lactation and led to 680 litres more over the entire lactation period
TRANSPORTATION
"If you apply FerAppease before the stress of transport, your average daily gain jumps from 20% to 30%."
— Dr. Reinaldo Fernandes Cooke, PhD, Department of Animal Science, Texas A&M University
1. Autumn T Pickett, Reinaldo F Cooke, Izadora S de Souza, Shea J Mackey, Administering the maternal bovine appeasing substance improves overall productivity and health in high-risk cattle during a 60-d feedlot receiving period, Journal of Animal Science, Volume 102, 2024, skae221.
2. Cooke, R. F., S. J. Mackey, I. S. de Souza, I. A. S. Mello, Y. M. Barreto, and V. N. Gouvea. 2024. Administering the maternal appeasing substance to Bos taurus and B. indicus cattle placed as yearlings in feedlots with different environmental conditions. Transl. Anim. Sci. txaf022.
3. Mackey, S. J., R. F. Cooke, and A. T. Pickett. 2024. Administering the maternal appeasing substance before slaughter to improve carcass characteristics of finishing cattle. Transl. Anim. Sci. 8:txae048.
4. Bringhenti, L., Colombo, E., Rodrigues, M. X., & Cooke, R. F. (2023). Effect of maternal bovine appeasing substance on health and performance of preweaned dairy calves. The Bovine Practitioner, 57(2), 1–4.
Prioritize Your Cattle's Welfare
Help your cattle respond better to stressful events while improving your profitability. Place your order today!
Happy Customers
FERAPPEASE IN THE FIELD
"An application of FerAppease when moving to the transition pen and repeated at calving has helped my heifers in their first 60 days. I have seen heifers take to the robot way more easily, let their colostrum down at first milking and then train to the routine much quicker than without. The heifers are already 2-3 litres per day up on daily milk by 14 days with peak yields looking to be 3 litres or more compared to previous performance. This is matching what the US data suggests and I am more than happy."
— Paul Symons, Standon Holsteins, Devon
In the Media
SPRING 2025
Pheromone Impact in Livestock
"The evidence to recommend UK cattle farmers use FerAppease mBAS is mounting."
— Rob Drysdale, BVM&S, MRCVS
FAQs
What is FerAppease?
The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (mBAS). mBAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect on the nursing offspring.
FerAppease is topically applied, and the active ingredient (mBAS) is assimilated by the vomeronasal gland located in the nose of the animals. The mBAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.
How do you apply FerAppease?
FerAppease is for use only in healthy cattle by topical administration in the divot behind the poll and to the skin above the muzzle.
When can FerAppease be used?
FerAppease can and should be used every time animals are exposed to management and physiological stressors where suppression of threat perception is desirable. i.e. weaning, dehorning, castration, branding, transportation, commingling, vaccination, parturition, interruption of lactation (dry off), breeding, et al.
What is the dosage of FerAppease on Cattle?
> 200 lb: Apply 5 mL of FerAppease in the divot behind the poll and a second 5 mL application to the skin above the muzzle.
< 200 lb: Apply 2.5 mL of FerAppease in the divot behind the poll and a second 2.5 mL application to the skin above the muzzle.
How long before FerAppease takes effect?
Behavior modulation and stress mitigation starts to take place immediately after FerAppease is applied.
Is a prescription required for FerAppease?
No, FerAppease does not require a veterinarian's prescription or a Veterinary Feed Directive plan.
Are there any side effects of FerAppease?
There are no known side effects.
Is there a withdrawal period after using FerAppease?
No, there is no withdrawal period after using FerAppease.
Can FerAppease be applied when it’s raining?
FerAppease is an oil-based product. It is recommended to apply FerAppease on a dry animal. It is best to allow FerAppease at least 30 minutes to absorb into the skin of the animal before getting wet.
What is the duration of each application?
FerAppease is effective for a period of 14 days. Most economically relevant, stressful events have a duration of less than 14 days. Therefore, a single application will get the animals through the entire challenge period.
Is there a benefit to reapplying FerAppease after the 14-day period?
If an animal is being run through the chute after the 14-day period for any reason such as revaccinating, studies have shown there are benefits to reapplication at this time.
Does FerAppease expire?
FerAppease has a two-year shelf life.
How should FerAppease be stored?
Store at controlled room temperature at 10 - 30℃ (50-86℉). Do not refrigerate or freeze.
Where can FerAppease be purchased?
FerAppease is available for purchase from veterinary clinics and through your Calibre Control, MWI Animal Health or NVS representatives, or on our website.
What is a p-value?
A p-value is a statistical measure used to determine the significance of results in a hypothesis test. It indicates the probability of obtaining the observed results if the null hypothesis (no effect or difference) is true. A low p-value (≤ 0.05) suggests rejecting the null hypothesis in favor of the alternative hypothesis (indicating an effect or difference), while a high p-value (> 0.05) suggests retaining the null hypothesis.
Can I request the full study data for FerAppease?
Yes, please email info@ferappease.co.uk
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